Short-Term Outcome of Inpatient Treatment for Adolescents with Anorexia Nervosa

Short-Term Outcome of Inpatient Treatment for Adolescents with Anorexia Nervosa Using DSM-5 Remission Criteria. 

This study evaluated the short-term outcome of a multimodal inpatient treatment concept for adolescents with anorexia nervosa (AN). In this prospective observational study, a cohort of 126 female adolescents with AN (age range: 11-17, mean age: 14.83) was longitudinally followed from admission to discharge (average duration of stay: 77 days).

We used gold-standard clinical interviews and self-report data, as well as DSM-5 remission criteria, to evaluate the treatment outcome. From admission to discharge, body-mass-index (BMI) significantly improved by 2.6 kg/m2.

Data from clinical interviews and self-reports yielded similar improvements in restraint eating and eating concerns (large effects). Lower effects were observed for variables assessing weight/shape concerns and drive for thinness.

At discharge, 23.2% of patients showed full remission of AN, 31.3% partial remission, and 45.5% no remission according to DSM-5 criteria. Differences in remission groups were found regarding AN severity, age at admission, and use of antidepressant medication.

Living with both parents, longer duration of inpatient treatment, and the use of antipsychotic medication were significantly associated with higher BMI change.

The findings provide evidence for the short-term effectiveness of our inpatient treatment concept. We recommend using DSM-5 based remission criteria to evaluate the treatment outcome to improve the comparability of studies.

Keywords: DSM-5; adolescents; anorexia nervosa; inpatient treatment; remission criteria; treatment evaluation. PMID: 34300355 PMCID: PMC8307185 DOI: 10.3390/jcm10143190 J Clin Med. 2021 Jul 20;10(14):3190. doi: 10.3390/jcm10143190.

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